Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer
Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells | Scientific Reports
Celecoxib Synergistically Enhances MLN4924-Induced Cytotoxicity and EMT Inhibition Via AKT and ERK Pathways in Human Urothelial Carcinoma - Shida Xiong, Wei Huang, Xiaoqiang Liu, Qian Chen, Yi Ding, Haoxuan Huang, Ru Zhang,
Cancers | Free Full-Text | Targeting NEDDylation as a Novel Approach to Improve the Treatment of Head and Neck Cancer
Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy | Cell Death Discovery
The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis | Cell Death Discovery
Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib
Neddylation regulation of mitochondrial structure and functions | Cell & Bioscience | Full Text
Continued ) F, schematic illustration of proposed mechanism underlying... | Download Scientific Diagram
Cancers | Free Full-Text | Drug Development Targeting the Ubiquitin–Proteasome System (UPS) for the Treatment of Human Cancers
Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy
A model for the role of MLN4924 in mtOr signaling inactivation.... | Download Scientific Diagram
Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication | Bentham Science
Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis | Cell Death & Disease
Frontiers | Neddylation: A Versatile Pathway Takes on Chronic Liver Diseases
SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma | Journal of Experimental & Clinical Cancer Research | Full Text
Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer | Cell Death Discovery
Frontiers | Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs
The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice | PNAS
Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy | Antioxidants & Redox Signaling
Figure 5 | Targeting the Neddylation Pathway to Suppress the Growth of Prostate Cancer Cells: Therapeutic Implication for the Men's Cancer
Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells | Scientific Reports
The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice | PNAS
Mechanism of MLN4924 action. Proposed mechanisms of how MLN4924... | Download Scientific Diagram
